St. Francis Minor Seminary and Senior High school was established in 1991 as a community-based day mixed secondary school with support and funding from World Vision International, an NGO. It was formal opened was on 4th March, 1991, at the day care centre also built by the same NGO with thirteen boys and five girls. Mr. Baffour Asare-Ahenkan acted as the Headmaster of the school until it was absorbed by the government of Ghana in January 1993. Mr. A. K. Manu was appointed as the first substantive headmaster. In 1996, the chieftaincy crisis at Buoyem nearly collapsed the school.
The community requested the assistance of the Catholic Church to manage the school in order to uplift its image and status in 2016. The conversion was completed in 2017 and the name of the school was changed from Buoyem Senior
High to St. Francis Seminary Senior High School. Its status has been changed to single sex (boys) school. The headship was also changed in March, 2018, with Rev. Fr. Martin Oduro Bilson becoming the first Rector and Headmaster of the
school, replacing Mr. Peter Blinyim, the then headmaster of the school. The motto of the school is Veritas, Sciencia et Mores. (Truth, knowledge and character).
